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181865-13-4

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181865-13-4 Structure

181865-13-4 Structure
IdentificationBack Directory
[Name]

1,7-Heptanediamine, N1,N7-bis(1,2,3,4-tetrahydro-9-acridinyl)-
[CAS]

181865-13-4
[Synonyms]

1,7-Heptanediamine, N1,N7-bis(1,2,3,4-tetrahydro-9-acridinyl)-
[Molecular Formula]

C33H40N4
[MOL File]

181865-13-4.mol
[Molecular Weight]

492.7
Chemical PropertiesBack Directory
[Melting point ]

81-82 °C
[Boiling point ]

736.8±60.0 °C(Predicted)
[density ]

1.172±0.06 g/cm3(Predicted)
[pka]

9.40±0.20(Predicted)
Hazard InformationBack Directory
[Definition]

ChEBI: Bis(7)-tacrine is a secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a neuroprotective agent, an EC 1.14.13.39 (nitric oxide synthase) inhibitor and an apoptosis inhibitor. It is functionally related to a tacrine.
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