| Identification | Back Directory | [Name]
Carbamimidothioic acid | [CAS]
182004-64-4 | [Synonyms]
Carbamimidothioic acid
Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester
2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, methanesulfonate (1:1) | [Molecular Formula]
C16H17N3O3S | [MDL Number]
MFCD00952138 | [MOL File]
182004-64-4.mol | [Molecular Weight]
331.39 |
| Chemical Properties | Back Directory | [Boiling point ]
98.4±23.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
0.37±0.10(Predicted) | [color ]
off-white to tan | [InChI]
1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4) | [InChIKey]
WGIKEBHIKKWJLG-UHFFFAOYSA-N | [SMILES]
CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1 |
| Hazard Information | Back Directory | [Uses]
2-[4-[(4-Nitrophenyl)methoxy]phenyl]ethyl Ester Carbamimidothioic Acid is an inhibitor of the reversed sodium-calcium exchanger (NCX). NCX is a potential therapeutic target for treatment in heart failure and myocardial ischemia-reperfusion. | [Biochem/physiol Actions]
KB-R7943 inhibits the reversed Na(+)/Ca(2+) exchanger, NCX. In cardiomyocytes, Ca2+ is released from intracellular stores during contraction, and sequestered again during relaxation. NCX is the primary mechanism that prevents Ca2+ overload due to influx of calcium across the plasma membrane. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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