| Identification | Back Directory | [Name]
2,6-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE | [CAS]
18206-06-9 | [Synonyms]
2,6-Dimethylisonicotinaldehyde
6-diMethylpyridine-4-carbaldehyde
2,6-DiMethylpyridine-4-carbaldehyde
2,6-diMethyl-4-Pyridinecarboxaldehyde
2,6-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE
4-Pyridinecarboxaldehyde, 2,6-dimethyl- | [Molecular Formula]
C8H9NO | [MDL Number]
MFCD06410687 | [MOL File]
18206-06-9.mol | [Molecular Weight]
135.16 |
| Chemical Properties | Back Directory | [Melting point ]
8℃ | [Boiling point ]
218℃ | [density ]
1.065 | [refractive index ]
1.5282 | [Fp ]
91℃ | [storage temp. ]
2-8°C, stored under nitrogen | [pka]
4.69±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2,6-dimethylpyridine-4-carbaldehyde from 2,6-dimethyl-4-hydroxymethylpyridine was as follows: 2,6-dimethyl-4-hydroxymethylpyridine (1.00 g, 7.30 mmol) was dissolved in acetonitrile (20 mL), and 1,2-benzoyl-3(1H)-keto-1-hydroxyl-1-oxo (IBX) (2.00 g, 7.30 mmol). The reaction mixture was heated to reflux for 6 hours. After completion of the reaction, the solid was removed by filtration and washed with acetonitrile. The filtrate was concentrated under reduced pressure to give 2,6-dimethylpyridine-4-carbaldehyde as a brown liquid. Yield: 0.81 g (82%). | [References]
[1] Patent: US9238640, 2016, B2. Location in patent: Page/Page column 134; 135
[2] Patent: US2013/281399, 2013, A1. Location in patent: Paragraph 0732; .0735; 0740; 0760; 0770; 0752
[3] Chemical Communications, 2015, vol. 51, # 61, p. 12258 - 12261 |
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