| Identification | Back Directory | [Name]
Sch 57068 | [CAS]
182167-02-8 | [Synonyms]
Em 652
Em-652
CS-1409
Sch 57068
ACOLBIFENE;EM652
Acolbifene (EM 652, SCH57068)
EM652; EM-652; SCH-57068; SCH 57068
EM 652; EM-652; EM652; SCH57068; SCH-57068; SCH 57068.
(S)-3-(4-hydroxyphenyl)-4-Methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol
(2S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol
2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-(4-(2-(1-piperidinyl)ethoxy)phenyl)-, (S)-
2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2S)-
( )-(2S)-3-(4-Hydroxyphenyl)-4-methyl-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-1-benzopyran-7-ol | [Molecular Formula]
C29H31NO4 | [MDL Number]
MFCD09837712 | [MOL File]
182167-02-8.mol | [Molecular Weight]
457.56 |
| Chemical Properties | Back Directory | [Boiling point ]
651.5±55.0 °C(Predicted) | [density ]
1.217±0.06 g/cm3(Predicted) | [solubility ]
DMSO:50.0(Max Conc. mg/mL);109.28(Max Conc. mM) | [form ]
A solid | [pka]
9.70±0.40(Predicted) | [color ]
White to pink |
| Hazard Information | Back Directory | [Uses]
Prevention
or treatment of breast and uterine proliferation or cancer. | [in vivo]
Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2].
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts[2].
| Animal Model: | Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g[2]. | | Dosage: | 2.5 mg/kg. | | Administration: | Oral gavage, once daily for 21 d. | | Result: | Prevents tumor growth in rats. |
| [IC 50]
ERα: 2 nM (IC50, E2-induced transcriptional activity); ERβ: 0.4 nM (IC50, E2-induced transcriptional activity) |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|