| Identification | Back Directory | [Name]
Propanoic acid, 2,2-dimethyl-, (2S)-3-[4-(2,2-dimethyl-1-oxopropoxy)phenyl]-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-yl ester | [CAS]
182167-03-9 | [Synonyms]
Propanoic acid, 2,2-dimethyl-, (2S)-3-[4-(2,2-dimethyl-1-oxopropoxy)phenyl]-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-yl ester | [Molecular Formula]
C39H47NO6 | [MDL Number]
MFCD00950716 | [MOL File]
182167-03-9.mol | [Molecular Weight]
625.79 |
| Hazard Information | Back Directory | [Uses]
EM-800, an orally active anti-estrogen, serves as an antagonist to the transcriptional functions of estrogen receptors α (ERα) and β (ERβ). EM-800 possesses anticancer activity, capable of inhibiting the growth of breast cancer induced by 7,12-Dimethylbenz[a]anthracene (DMBA) (HY-W011845). Furthermore, in ovariectomized animals, EM-800 effectively slows down bone loss. Additionally, EM-800 shows potential in the research of breast and endometrial cancers, while exerting beneficial effects on bone and lipid metabolism[1][2]. | [References]
[1] Tremblay A, et al. EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Endocrinology. 1998 Jan;139(1):111-8. DOI:10.1210/endo.139.1.5702
[2] Labrie F, et al. EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):51-84. DOI:10.1016/s0960-0760(99)00065-5 |
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