| Identification | Back Directory | [Name]
Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- | [CAS]
182182-32-7 | [Synonyms]
Exatecan Intermediate 7
Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- | [Molecular Formula]
C13H13FN2O3 | [MOL File]
182182-32-7.mol | [Molecular Weight]
264.25 |
| Chemical Properties | Back Directory | [Boiling point ]
536.4±50.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.93±0.20(Predicted) | [color ]
Light green to green |
| Hazard Information | Back Directory | [Uses]
Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs). | [IC 50]
Camptothecins | [References]
[1] Kamihara, et al. Aminotetralone derivatives and process for producing the same. World Intellectual Property Organization, WO9626181 A1 1996-08-29.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x |
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