| Identification | Back Directory | [Name]
SGC2085 | [CAS]
1821908-48-8 | [Synonyms]
CS-2529
CS-2688
SGC-2085; SGC 2085
Propanamide, 2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]-, (2S)- | [Molecular Formula]
C19H24N2O2 | [MDL Number]
MFCD30537226 | [MOL File]
1821908-48-8.mol | [Molecular Weight]
312.41 |
| Chemical Properties | Back Directory | [Boiling point ]
498.3±45.0 °C(Predicted) | [density ]
1.097±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO : ≥ 32 mg/mL (102.43 mM) | [form ]
Solid | [pka]
14.83±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins[1]. | [IC 50]
PRMT4 | [References]
[1] Ferreira de Freitas R, et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47. DOI:10.1021/acs.jmedchem.6b00668 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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