| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, N-[3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl]amino]propyl]-N-[4-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][2-(4-isothiocyanatophenyl)ethyl]amino]propyl]amino]butyl]-1,6-dihydro-1-hydroxy-6-oxo- | [CAS]
1822331-55-4 | [Synonyms]
p-SCN-Bn-HOPO
2-Pyridinecarboxamide, N-[3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl]amino]propyl]-N-[4-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl][2-(4-isothiocyanatophenyl)ethyl]amino]propyl]amino]butyl]-1,6-dihydro-1-hydroxy-6-oxo- | [Molecular Formula]
C43H45N9O12S | [MOL File]
1822331-55-4.mol | [Molecular Weight]
911.94 |
| Hazard Information | Back Directory | [Description]
p-SCN-Bn-HOPO is a superior bifunctional chelator for (89)Zr ImmunoPET. In vivo studies demonstrate the successful use of (89)Zr-HOPO-trastuzumab to image BT474 breast cancer with low background, good tumor to organ contrast, and, importantly, very low bone uptake. The reduced bone uptake seen with (89)Zr-HOPO-trastuzumab suggests superior stability of the (89)Zr-HOPO complex. | [Uses]
p-SCN-Bn-HOPO is a bifunctional chelating agent. p-SCN-Bn-HOPO is used to bind to the radioactive isotope zirconium-89 (^89Zr) for use in ImmunoPET[1]. | [References]
[1] Deri M A, et al. p-SCN-Bn-HOPO: a superior bifunctional chelator for 89Zr immunoPET[J]. Bioconjugate chemistry, 2015, 26(12): 2579-2591. DOI:10.1021/acs.bioconjchem.5b00572 |
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ChemShuttle, Inc.
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0510-83588313-811 18800520310 |
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www.jiehuapharma.com/ |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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