| Identification | Back Directory | [Name]
Benzamide, 4-fluoro-N-methyl-N-[1-[2-[(1-methyl-1H-pyrazol-5-yl)amino]benzoyl]-4-piperidinyl]-2-(trifluoromethyl)- | [CAS]
1822355-27-0 | [Synonyms]
SMO-IN-2
Benzamide, 4-fluoro-N-methyl-N-[1-[2-[(1-methyl-1H-pyrazol-5-yl)amino]benzoyl]-4-piperidinyl]-2-(trifluoromethyl)- | [Molecular Formula]
C25H25F4N5O2 | [MOL File]
1822355-27-0.mol | [Molecular Weight]
503.49 |
| Chemical Properties | Back Directory | [Boiling point ]
661.9±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.24±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1]. | [References]
[1] Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354. DOI:10.1016/j.bmc.2020.115354 |
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