| Identification | Back Directory | [Name]
9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester | [CAS]
182261-83-2 | [Synonyms]
9H-Carbazole-3-carboxylic acid, 1-hydroxy-, methyl ester | [Molecular Formula]
C14H11NO3 | [MOL File]
182261-83-2.mol | [Molecular Weight]
241.24 |
| Hazard Information | Back Directory | [Uses]
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells. | [Definition]
ChEBI: Clausine E is a member of carbazoles. It has a role as a metabolite. | [References]
[1] Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800. DOI:10.1002/jmr.2800
[2] Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445. DOI:10.19540/j.cnki.cjcmm.20210429.203
[3] Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619. DOI:10.1016/j.bmc.2007.05.033 |
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