| Identification | Back Directory | [Name]
Thalidezine | [CAS]
18251-36-0 | [Synonyms]
Thalidezine
Thalidesine
Thalidezine USP/EP/BP
5-O-DeMethylhernandezine
16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-20-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aS)- | [Molecular Formula]
C38H42N2O7 | [MOL File]
18251-36-0.mol | [Molecular Weight]
638.75 |
| Chemical Properties | Back Directory | [Melting point ]
158-159℃ | [Boiling point ]
735.0±60.0 °C(Predicted) | [density ]
1.206±0.06 g/cm3 (20 ºC 760 Torr) | [pka]
9.71±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
A further alkaloid of the bisbenzylisoquinoline type found in Thalictrum
fendleri Engelm, this base yields colourless crystals from Me2CO and has [α]25D +
236° (CHCl3). The ultraviolet spectrum has one absorption maximum at 283 mJ.1.
The D-methyl ether is identical with Hernandezine (q.v.). The D-ethy1 ether
forms colourless crystals with m.p. 117-120° C. | [Uses]
Thalidezine is an isoquinoline alkaloid used in the treatments of cancers and neurodegenerative diseases. | [References]
Shamma, Shine, Dudock., Tetrahedron, 23, 2887 (1967) |
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