| Identification | Back Directory | [Name]
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) | [CAS]
182912-74-9 | [Synonyms]
IAB5
IAβ5
LPFFD
IA-BETA5
LEU-PRO-PHE-PHE-ASP
H-LEU-PRO-PHE-PHE-ASP-OH
Beta-Sheet Breaker Peptide iAβ5
[PRO18, ASP21] BETA-AMYLOID (17-21)
BETA-SHEET BREAKER PEPTIDE IA-BETA5
BETA-SHEET BREAKER PEPTIDE IA-BETA5P
A-BETA42 FIBRILLOGENESIS INHIBITOR I
(Pro18,Asp21)-Amyloid β-Protein (17-21)
[Pro18, Asp21] beta-Amyloid (17-21), iAb5
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21)
AMYLOID BETA42 FIBRILLOGENESIS INHIBITOR I
[Pro18, Asp21] β - Amyloid (17 - 21), iAb5
(PRO18,ASP21)AMYLOID BETA PROTEIN*FRAGMENT (17-21)
(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21) USP/EP/BP
(Pro18,Asp21)-Amyloid b-Protein (17-21) trifluoroacetate salt
[PRO18, ASP21]AMYLOID-BETA PROTEIN (17-21), HUMAN, MOUSE, RAT
L-Aspartic acid, L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-
[PRO18, ASP21]-AMYLOID B PROTEIN FRAGMENT 17-21 TRIFLUOROACETATE SALT
[pro18, asp21]-amyloid β protein fragment 17-21 trifluoroacetate salt
[Pro18, Asp21]-AMyloid beta Protein FragMent 17-21 trifluoroacetate salt | [Molecular Formula]
C33H43N5O8 | [MDL Number]
MFCD01862668 | [MOL File]
182912-74-9.mol | [Molecular Weight]
637.72 |
| Chemical Properties | Back Directory | [Boiling point ]
980.0±65.0 °C(Predicted) | [density ]
1.291±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic | [form ]
solid | [pka]
2.88±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Leu-Pro-Phe-Phe-Asp |
| Hazard Information | Back Directory | [Uses]
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination. | [in vivo]
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat; Intra-amygdala injection; 7 days) coinjected with Aβ1-42 (5 nmol) into in the rat amygdala, blocks Aβ1-42 neurotoxicity in tissue culture, and amyloid fibril formation in the rat model[1].
β-Sheet Breaker Peptide iAβ5 (100 nmol/rat, 200 nmol/rat; Intra-amygdaloid injection; 7 days) followed by Aβ1-42 (5 nmol), induces disassembly of pre-existing Aβ fibrils in vivo, and leads to a reversal or prevention of Aβ-induced histopathological changes in rat model[2].
| [storage]
Store at -20°C | [References]
[1] Soto C, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med. 1998 Jul;4(7):822-6. DOI:10.1038/nm0798-822
[2] Sigurdsson EM, et al. In vivo reversal of amyloid-beta lesions in rat brain. J Neuropathol Exp Neurol. 2000 Jan;59(1):11-7. DOI:10.1093/jnen/59.1.11
[3] Okada Y, et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Org Lett. 2015 Sep 4;17(17):4264-7. DOI:10.1021/acs.orglett.5b02057 |
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