| Identification | Back Directory | [Name]
1-Azetidinecarbonitrile, 3-([1,1'-biphenyl]-4-ylmethoxy)- | [CAS]
1831115-59-3 | [Synonyms]
NAAA-IN-3
1-Azetidinecarbonitrile, 3-([1,1'-biphenyl]-4-ylmethoxy)- | [Molecular Formula]
C17H16N2O | [MOL File]
1831115-59-3.mol | [Molecular Weight]
264.32 |
| Hazard Information | Back Directory | [Uses]
NAAA-IN-3 (Compound 17a) is a potent and selective inhibitor of NAAA with an IC50 of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-3 has the potential for the research of inflammation and pain[1]. | [References]
[1] Malamas MS, et al. Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem. 2020 Jan 1;28(1):115195. DOI:10.1016/j.bmc.2019.115195 |
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