| Identification | Back Directory | [Name]
7-((1-Benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate | [CAS]
1831135-46-6 | [Synonyms]
ABC44
7-((1-Benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate
4-(4-METHOXYPHENYL)-1-PIPERAZINECARBOXYLIC ACID HEXAHYDRO-1,3-DIOXO-7-[[1-(PHENYLMETHYL)-4-PIPERIDINYL]METHYL]IMIDAZO[1,5-A]PYRAZIN-2-YL ESTER | [Molecular Formula]
C31H40N6O5 | [MDL Number]
MFCD30718584 | [MOL File]
1831135-46-6.mol | [Molecular Weight]
576.69 |
| Chemical Properties | Back Directory | [Boiling point ]
689.8±65.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10mg/mL, clear | [form ]
Solid | [pka]
8.82±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
YHRQLTHMALGXOG-UHFFFAOYSA-N | [SMILES]
O=C(N1OC(N2CCN(C3=CC=C(OC)C=C3)CC2)=O)C(CN(CC4CCN(CC5=CC=CC=C5)CC4)CC6)N6C1=O |
| Hazard Information | Back Directory | [Uses]
ABC44 is a potent serine hydrolase inhibitor with IC50s of 0.1 μM and 6.5 μM for palmitoyl protein thioesterase 1 (PPT1) in situ and in vitro, respectively. ABC44 can be used for researching infantile neuronal ceroid lipofuscinosis[1]. | [Biological Activity]
ABC44 is a cell-activepotent and selective inhibitor of palmitoyl-protein thioesterase 1 (PPT-1). | [References]
[1] Cognetta AB 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chem Biol. 2015 Jul 23;22(7):928-37. DOI:10.1016/j.chembiol.2015.05.018 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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