| Identification | Back Directory | [Name]
1,1,1-Trifluoroethyl-PEG3-Propargyl | [CAS]
1835759-73-3 | [Synonyms]
1,1,1-Trifluoroethyl-PEG3-Propargyl
1,1,1-Trifluoroethyl-PEG2-propargyl
1-Propyne, 3-[2-[2-(2,2,2-trifluoroethoxy)ethoxy]ethoxy]- | [Molecular Formula]
C9H13F3O3 | [MDL Number]
MFCD29052201 | [MOL File]
1835759-73-3.mol | [Molecular Weight]
226.19 |
| Chemical Properties | Back Directory | [Boiling point ]
243.5±35.0 °C(Predicted) | [density ]
1.152±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
1,1,1-Trifluoroethyl-PEG3-Propargyl is a heterobifunctional reagent with an alkyne group and a trifluoroethyl group. The alkyne group reacts with azide compounds or biomolecules in copper catalyzed Click Chemistry to form a stable triazole linkage. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces. | [Uses]
1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|