| Identification | Back Directory | [Name]
Human lactoferrin peptide 1-11 | [CAS]
183623-03-2 | [Synonyms]
Human lactoferrin peptide 1-11
L-Alanine, glycyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-seryl-L-valyl-L-glutaminyl-L-tryptophyl-L-cysteinyl- | [Molecular Formula]
C56H95N25O14S | [MOL File]
183623-03-2.mol | [Molecular Weight]
1374.58 |
| Hazard Information | Back Directory | [Uses]
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses[1][2]. | [in vivo]
hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits[4].
hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice[6].
| Animal Model: | Rabbits inoculated with CFU MRSA[4] | | Dosage: | 20 mg/kg | | Administration: | Injected into the debrided tibial cavity | | Result: | Reduced bacterial load compared to controls, and reduced the radiological and histopathological score. |
| Animal Model: | Neutropenic mice challenged i.v. with C. albicans | | Dosage: | 40 μg/kg | | Administration: | Intravenous injection (i.v) | | Result: | Reduced serum TNFα and IL-6 in infected mice. |
| [References]
[1] Marty Wulferink, et al. The Peptide hLF1-11 as Broad Spectrum Antmicrobial Prophylaxis in HSCT Patients. Blood (2005) 106 (11): 3241.
[2] van der Does AM, et al. Antimicrobial peptide hLF1-11 directs granulocyte-macrophage colony-stimulating factor-driven monocyte differentiation toward macrophages with enhanced recognition and clearance of pathogens. Antimicrob Agents Chemother. 2010 Feb;54(2):811-6. DOI:10.1128/AAC.00652-09
[3] van der Does AM, et al. The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity. J Immunol. 2012 May 15;188(10):5012-9. DOI:10.4049/jimmunol.1102777
[4] Faber C, et al. Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. Antimicrob Agents Chemother. 2005 Jun;49(6):2438-44. DOI:10.1128/AAC.49.6.2438-2444.2005
[5] Lupetti A, et al. Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob Agents Chemother. 2000 Dec;44(12):3257-63. DOI:10.1128/AAC.44.12.3257-3263.2000
[6] upetti A, et al. Human lactoferrin-derived peptide's antifungal activities against disseminated Candida albicans infection. J Infect Dis. 2007 Nov 1;196(9):1416-24. DOI:10.1086/522427 |
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