| Identification | Back Directory | [Name]
3,5-Dichloropyridazine | [CAS]
1837-55-4 | [Synonyms]
SA029519
5-Dichloropyridazine
3,5-Dichloropyridazine
Pyridazine,3,5-dichloro-
3,5-Dichloropyridazine>
3,5-Dichloropyridazine ISO 9001：2015 REACH | [Molecular Formula]
C4H2Cl2N2 | [MDL Number]
MFCD10698048 | [MOL File]
1837-55-4.mol | [Molecular Weight]
148.98 |
| Chemical Properties | Back Directory | [Melting point ]
60.0 to 64.0 °C | [Boiling point ]
280.8±20.0 °C(Predicted) | [density ]
1.493±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
-0.25±0.10(Predicted) | [color ]
Yellow to Dark Orange | [InChI]
InChI=1S/C4H2Cl2N2/c5-3-1-4(6)8-7-2-3/h1-2H | [InChIKey]
JZSAUQMXKHBZEO-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NN=CC(Cl)=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow solid powder. | [Uses]
3,5-Dichloropyridazine used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects
| [Application]
3,5-Dichloropyridazine can be used as a pharmaceutical reaction intermediate, for example, in the preparation of the compound 3-chloro-5-aminopyridazine. These compounds are commonly used chemical synthesis intermediates and have been widely applied in the research and development of drugs and pesticides in recent years, such as anticancer drugs (US2004/54186) and plant growth regulators (US1988/4728355). | [Definition]
ChEBI: 3,5-Dichloropyridazine is a member of pyridazines. | [Preparation]
Preparation of 3,5-Dichloropyridazine:
2,4,4,4-Tetrachlorocrotonaldehyde is dissolved in a solvent, and a mixture of semicarbazide hydrochloride, water, and solvent is added dropwise under controlled temperature conditions. The reaction is stirred for 5 hours. Afterward, the reaction mixture is concentrated under reduced pressure to remove the solvent. Water is added, and the temperature is lowered to 5°C, allowing a solid to precipitate. The solid is filtered and recrystallized using a dichloromethane/petroleum ether mixture, yielding 3,5-dichloropyridazine as a white crystalline solid. |
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Cool Pharm, Ltd Gold
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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