| Identification | Back Directory | [Name]
AM 404 | [CAS]
183718-77-6 | [Synonyms]
AM 404
N-(4-HYDROXYPHENYL)-ARACHIDONAMIDE
N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE
N-(4-HYDROXYPHENYL) ARACHIDONOYLAMIDE
ARACHIDONOYLAMIDE, N-(4-HYDROXYPHENYL)
N-(4-HYDROXYPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRENAMIDE
N-(4-HYDROXYPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
(all-Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenaMide
(5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenaMide
5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)- | [EINECS(EC#)]
200-578-6 | [Molecular Formula]
C26H37NO2 | [MDL Number]
MFCD03095721 | [MOL File]
183718-77-6.mol | [Molecular Weight]
395.58 |
| Chemical Properties | Back Directory | [Boiling point ]
579.4±50.0 °C(Predicted) | [density ]
1.007±0.06 g/cm3(Predicted) | [Fp ]
14 °C | [storage temp. ]
-20°C | [solubility ]
ethanol: 24 mg/mL Photosensitive solution. | [form ]
solution | [pka]
10.11±0.26(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
It is a metabolite of the well-known analgesic Paracetamol.
ase (FAAH) in vivo. | [Uses]
Potentiates the activity of endogenous anandamide by blocking its re-uptake into presynaptic membranes. AM404 selectively inhibits the carrier-mediated transport of anandamide without affecting anandamide hydrolysis. | [in vivo]
AM404 (1-5 mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations. | Animal Model: | Adult male Sprague-Dawley rats (250-300?g)[2] | | Dosage: | 2.5-10?mg/kg | | Administration: | Intraperitoneal (i.p.) | | Result: | Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.
|
| [storage]
-20°C |
|
| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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