| Identification | Back Directory | [Name]
Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- | [CAS]
1838123-22-0 | [Synonyms]
(R,R)-CXCR2-IN-2
Urea, N-[4-chloro-2-hydroxy-3-[[(3R)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]- | [Molecular Formula]
C18H23ClN2O5S | [MDL Number]
MFCD34167537 | [MOL File]
1838123-22-0.mol | [Molecular Weight]
414.9 |
| Chemical Properties | Back Directory | [Boiling point ]
573.7±50.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 220 mg/mL (530.25 mM; Need ultrasonic) | [form ]
Solid | [pka]
4.99±0.10(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1]. | [Biological Activity]
(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1]. | [References]
[1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532. |
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