| Identification | Back Directory | [Name]
2H,6H,10H-Benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one, 7,8,11,12-tetrahydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-, (10R,11S,12S)- | [CAS]
183904-53-2 | [Synonyms]
NSC 678323|||DHCal A
(+)-Dihydrocalanolide A
2H,6H,10H-Benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one, 7,8,11,12-tetrahydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-, (10R,11S,12S)- | [Molecular Formula]
C22H28O5 | [MOL File]
183904-53-2.mol | [Molecular Weight]
372.45 |
| Hazard Information | Back Directory | [Uses]
(+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally active nonnucleoside inhibitor of Reverse Transcriptase. (+)-Dihydrocalanolide A can be used to HIV infection research[1]. | [in vivo]
(+)-Dihydrocalanolide A (25 mg/kg; p.o.; single dose) shows good pharmacokinetic parameters, with oral bioavailability in CD2F1 mice of 64%[1].
| [References]
[1] Newman RA, et al. Pharmaceutical properties of related calanolide compounds with activity against human immunodeficiency virus. J Pharm Sci. 1998 Sep;87(9):1077-80. DOI:10.1021/js980122d |
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