| Identification | Back Directory | [Name]
pereirine | [CAS]
18397-07-4 | [Synonyms]
pereirine
Geissoschizoline
(16α)-Curan-17-ol
16Betah-curan-17-ol
Curan-17-ol, (16α)-
(16alpha)-Curan-17-ol
(16Betah)-curan-17-ol
Curan-17-ol, (16alpha)-
Inchi=1/C19H26N2o/C1-2-12-10-21-8-7-19-15-5-3-4-6-16(15)20-18(19)14(11-22)13(12)9-17(19)21/H3-6,12-14,17-18,20,22H,2,7-11H2,1H3/T12-,13+,14+,17+,18+,19-/m1/s | [EINECS(EC#)]
242-275-1 | [Molecular Formula]
C19H26N2O | [MOL File]
18397-07-4.mol | [Molecular Weight]
298.42 |
| Chemical Properties | Back Directory | [Melting point ]
142.5-143° | [alpha ]
D21 +32° (ethanol) | [Boiling point ]
439.83°C (rough estimate) | [density ]
1.0523 (rough estimate) | [refractive index ]
1.5600 (estimate) | [pka]
14.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 μM and 10.21 μM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent[1]. | [Definition]
ChEBI: An indole alkaloid that is (16alpha)-curan substituted by a hydroxy group at position 17. | [References]
[1] Josélia A Lima, et al. Geissoschizoline, a promising alkaloid for Alzheimer's disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorg Chem. 2020 Nov;104:104215. DOI:10.1016/j.bioorg.2020.104215 |
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