| Identification | Back Directory | [Name]
5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE | [CAS]
184241-44-9 | [Synonyms]
NBI27914HCl
NBI 27914 hydrochlor
NBI 27914 >=98% (HPLC)
NBI 27914 HYDROCHLORIDE
5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride
5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE | [Molecular Formula]
C18H20Cl4N4 | [MDL Number]
MFCD05662281 | [MOL File]
184241-44-9.mol | [Molecular Weight]
434.19 |
| Chemical Properties | Back Directory | [Boiling point ]
483.7±45.0 °C(Predicted) | [density ]
1.417±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 16 mg/mL at 60 °C, soluble | [form ]
solid | [pka]
3.58±0.50(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
| [Definition]
ChEBI: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine is a dialkylarylamine and a tertiary amino compound. | [Biological Activity]
Selective, non-peptide corticotropin-releasing factor 1 (CRF 1 ) receptor antagonist (K i = 1.7 nM); has no activity at CRF 2 receptors. Blocks behavioral seizures in vivo . | [Biochem/physiol Actions]
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist. |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|