| Identification | Back Directory | [Name]
Androsta-11,16-diene-14-carboxylic acid, 4,4,8,12,16-pentamethyl-17-hydroxy-3,15-dioxo-, methyl ester, (5β,8α,9β,10α,13α)- | [CAS]
184432-08-4 | [Synonyms]
Androsta-11,16-diene-14-carboxylic acid, 4,4,8,12,16-pentamethyl-17-hydroxy-3,15-dioxo-, methyl ester, (5β,8α,9β,10α,13α)- | [Molecular Formula]
C26H36O5 | [MOL File]
184432-08-4.mol | [Molecular Weight]
428.57 |
| Hazard Information | Back Directory | [Uses]
Andrastin D is a protein farnesyltransferase inhibitor. Andrastin D has a common androstane skeleton[1]. | [Definition]
ChEBI: Andrastin D is a 3-oxo steroid that is andrastin C in which the acetoxy group at the 3beta position has undergone formal oxidative cleavage to afford the corresponding 3-oxo derivative. A farnesyltransferase inhibitor produced by Penicillium roqueforti, a filamentous fungus involved in the ripening of several kinds of blue cheeses. It has a role as a Penicillium metabolite and an EC 2.5.1.58 (protein farnesyltransferase) inhibitor. It is a 3-oxo steroid, a 15-hydroxy steroid, a 5beta steroid, a 17-oxo steroid, an enol, a meroterpenoid and a methyl ester. It is a conjugate acid of an andrastin D(1-). | [References]
[1] Uchida R, et al. Andrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929. J Antibiot (Tokyo). 1996 Dec;49(12):1278-80. DOI:10.7164/antibiotics.49.1278 |
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