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1848962-29-7

1848962-29-7 Structure

1848962-29-7 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

1848962-29-7
[Synonyms]

Kisspeptin 234(TFA)
[Molecular Formula]

C65H79F3N18O15
[MOL File]

1848962-29-7.mol
[Molecular Weight]

1409.45
Chemical PropertiesBack Directory
[solubility ]

DMF: Slightly Soluble
DMSO: Slightly Soluble
[form ]

Solid
[color ]

White to off-white
[Sequence]

Ac-Ala-Asn-Trp-Asn-Gly-Phe-Gly-Trp-Arg-Phe-NH2
Hazard InformationBack Directory
[Uses]

Kisspeptin 234 TFA, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 TFA is an analog of Kisspeptin 10[1].
[in vivo]

Kisspeptin 234 (1 mg/kg, ip, daily, 28 days) TFA can inhibit the anti-fibrotic effect of Kisspeptin-13 in the bleomycin (BLM)-induced lung fibrosis model of C57BL/6 mice, especially in weight loss, decreased survival rate, increased lung coefficient, and massive infiltration[1].

[References]

[1] Lei Z, et al. Kisspeptin?13 inhibits bleomycin?induced pulmonary fibrosis through GPR54 in mice. Mol Med Rep. 2019 Aug;20(2):1049-1056. DOI:10.3892/mmr.2019.10341
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