| Identification | Back Directory | [Name]
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, acetate (1:3) | [CAS]
1849610-71-4 | [Synonyms]
Elamipretide TriTFA
Elamipretide Triacetate
L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, acetate (1:3) | [Molecular Formula]
C34H53N9O7 | [MOL File]
1849610-71-4.mol | [Molecular Weight]
699.85 |
| Hazard Information | Back Directory | [Uses]
Elamipretide triacetate (MTP-131 triacetate; RX-31 triacetate; SS-31 triacetate) is Elamipretide triacetate form of Elamipretide (HY-P0125). Elamipretide triacetate is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2]. | [in vivo]
Elamipretide triacetate (5 mg/kg, i.p., once daily for 3 days) exhibits neuroprotective effects, protects the hippocampus from mitochondrial dysfunction, and attenuates the oxidative stress and inflammatory response in Lipopolysaccharide (HY-D1056)-induced cognitive impairment in C57BL/6 mice model[1].
| Animal Model: | LPS-induced cognitive impairment in C57BL/6 mice model[1] | | Dosage: | 5 mg/kg | | Administration: | i.p., once daily for 3 days | | Result: | Maintained the mitochondrial function, ROS and MDA levels, and SOD activity.
Inhibited neural cell apoptosis in hippocampus, enhanced the hippocampal BDNF pathway and synaptic structural complexity. |
| [References]
[1] Zhao W, et al., Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. J Neuroinflammation. 2019 Nov 20;16(1):230. DOI:10.1186/s12974-019-1627-9
[2] Sabbah HN,et al., Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure. Circ Heart Fail. 2016 Feb;9(2):e002206. DOI:10.1161/CIRCHEARTFAILURE.115.002206 |
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