| Identification | Back Directory | [Name]
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE | [CAS]
185040-32-8 | [Synonyms]
4-MethylaMino-2-MethylsulfanylpyriMidine
4-(MethylaMino)-2-(Methylthio)pyriMidine-5-carboxald
4-MethylaMino-2-MethanethiopyriMidine-5-
carboxaldehyde
4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
4-(METHYLAMINO)-2-(METHYLTHIO)-5-PYRIMIDINE CARBALDEHYDE
4-(MethylaMino)-2-(Methylthio)-5-pyriMidinecarboxaldehyde
4-(Methylamino)-2-(methylthio)pyrimidine-5-carboxaldehyde
5-Pyrimidinecarboxaldehyde, 4-(methylamino)-2-(methylthio)-
4-MethylaMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde
4-(MethylaMino)-2-(Met
hylsulfanyl)pyriMidine-5-carboxaldehyde
4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH | [Molecular Formula]
C7H9N3OS | [MDL Number]
MFCD04115117 | [MOL File]
185040-32-8.mol | [Molecular Weight]
183.23 |
| Chemical Properties | Back Directory | [Melting point ]
99-101 °C | [Boiling point ]
377.1±27.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol | [form ]
Solid | [pka]
3.15±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Intermediate in the preparation of p38 kinase inhibitors | [Synthesis]
In a dry 3L three-necked round-bottomed flask equipped with an overhead mechanical stirrer and an argon inlet, 32.74 g (176.7 mmol) of (4-methylamino-2-methanesulfonyl-pyrimidin-5-yl)-methanol was dissolved in 1.6 L of chloroform. Under stirring conditions, 152 g (1.75 mol) of manganese dioxide was added in batches. The reaction mixture was slightly heated and stirred continuously for 7 hours. Upon completion of the reaction, vacuum filtration was performed through a diatomaceous earth pad to remove the manganese dioxide and the filter cake was washed well with two 300mL portions of chloroform. The filtrates were combined and concentrated to give a white solid product. After vacuum drying, 30.6 g (94% yield) of 4-methylamino-2-methylthio-5-formylpyrimidine was obtained. The spectral data of the obtained product were in agreement with the values reported in the literature. | [References]
[1] Patent: WO2004/63195, 2004, A1. Location in patent: Page 53-54
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 17, p. 3276 - 3292
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 355
[4] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 88
[5] Patent: WO2014/11900, 2014, A2. Location in patent: Page/Page column 31; 32 |
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