| Identification | Back Directory | [Name]
8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT | [CAS]
185341-71-3 | [Synonyms]
8-Cl-ATP
8-CL-ATP SODIUM SALT
8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT
8-chloroadenosine-5’-triphosphate(8-cl-atp),sodiumsalt | [Molecular Formula]
C10H11ClN5Na4O13P3 | [MDL Number]
MFCD04118027 | [MOL File]
185341-71-3.mol | [Molecular Weight]
629.55 |
| Hazard Information | Back Directory | [Uses]
8-Chloro-ATP, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP inhibits Topo II-catalyzed ATP hydrolysis[1]. | [IC 50]
Topoisomerase II | [References]
[1] Sheng-Yong Yang, et al. Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells. Biochem Pharmacol. 2009 Feb 1;77(3):433-43. DOI:10.1016/j.bcp.2008.10.022 |
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