| Identification | Back Directory | [Name]
3-AMINO-6-METHYLPYRIDAZINE | [CAS]
18591-82-7 | [Synonyms]
3-Ami-6-methylpyridazine
6-Methylpyridazin-3-amin
6-METHYLPYRIDAZIN-3-AMINE
6-Methyl-3-pyridazinamine
6-methyl-3-aminopyridazine
3-AMINO-6-METHYLPYRIDAZINE
3-PyridazinaMine, 6-Methyl-
6-methylpyridazine-3-ylamine
3-Amino-6-methylpyridazin...
6-Methylpyridazin-3-amine, tech
3-AMINO-6-METHYLPYRIDAZINE ISO 9001：2015 REACH
6-Methylpyridazin-3-amine, 3-Amino-6-methyl-1,2-diazine | [EINECS(EC#)]
242-430-3 | [Molecular Formula]
C5H7N3 | [MDL Number]
MFCD01569899 | [MOL File]
18591-82-7.mol | [Molecular Weight]
109.13 |
| Chemical Properties | Back Directory | [Melting point ]
222-223℃ | [Boiling point ]
319℃ | [density ]
1.155 | [Fp ]
173℃ | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [pka]
5.48±0.10(Predicted) | [color ]
very dark red/brown | [InChI]
InChI=1S/C5H7N3/c1-4-2-3-5(6)8-7-4/h2-3H,1H3,(H2,6,8) | [InChIKey]
KAZMCIGKULUUMR-UHFFFAOYSA-N | [SMILES]
C1(N)=NN=C(C)C=C1 |
| Questions And Answer | Back Directory | [Uses]
Pyridazines are an important class of aromatic heterocyclic compounds with strong antiviral, hypotensive, cardiotonic, and anticancer physiological activities. 6-Methyl-3-aminopyridazine is a heterocyclic organic compound and can be used as a very important pharmaceutical and chemical intermediate. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
WGK 3 | [HazardClass ]
IRRITANT | [HS Code ]
2933998090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Synthesis]
Step A: A mixture of 3-chloro-6-methylpyridazine (516 mg, 4.0 mmol), NH4OH (30%, 3 mL), and copper(II) sulfate pentahydrate (26 mg, 0.2 mmol) was stirred for 40 hours at 120 °C. After completion of the reaction, the mixture was cooled to room temperature and partitioned between EtOAc and brine. The aqueous layer was extracted five times with EtOAc. The combined organic phases were dried with anhydrous Na2SO4, filtered and concentrated, and purified by silica gel column chromatography (elution gradient: 0-10% MeOH in CH2Cl2 solution) to afford 6-methylpyridazin-3-amine (160 mg, 37% yield) as a white solid. ms m/z 109.9 [M + H]+. | [References]
[1] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 386; 387
[2] Patent: WO2006/102194, 2006, A1. Location in patent: Page/Page column 25
[3] Patent: WO2006/107784, 2006, A1. Location in patent: Page/Page column 33
[4] Chemische Berichte, 1948, vol. 81, p. 1,10
[5] Journal of the Chemical Society, 1947, p. 239,242 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
| Company Name: |
Aemon Chemical
|
| Telephone: |
0086-755-86198205 |
| Website: |
www.aemonchem.com |
|