| Identification | Back Directory | [Name]
AMD 3465 (*Hexahydrobromide*) | [CAS]
185991-07-5 | [Synonyms]
CS-810
AMD 3465
AMD3465,98%
GENZ-644494
AMD 3465 (hydrobroMide)
AMD3465;AMD-3465;AMD 3465
AMD 3465 (*Hexahydrobromide*)
AMD3465 R10406hexahydrobromide
1-(2-Pyridinyl)-N-[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)benzyl]MethanaMine
N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide | [Molecular Formula]
C24H38N6 | [MDL Number]
MFCD20926342 | [MOL File]
185991-07-5.mol | [Molecular Weight]
410.599 |
| Chemical Properties | Back Directory | [Melting point ]
>200°C (dec.) | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) | [form ]
powder | [color ]
white to light brown | [Water Solubility ]
H2O: 25mg/mL, clear | [InChI]
1S/C24H38N6/c1-2-13-29-24(5-1)20-28-19-22-6-8-23(9-7-22)21-30-17-4-12-26-15-14-25-10-3-11-27-16-18-30/h1-2,5-9,13,25-28H,3-4,10-12,14-21H2 | [InChIKey]
CWJJHESJXJQCJA-UHFFFAOYSA-N | [SMILES]
N3(CCNCCCNCCNCCC3)Cc1ccc(cc1)CNCc2ncccc2 |
| Hazard Information | Back Directory | [Uses]
AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma | [Biochem/physiol Actions]
AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100. | [in vivo]
AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts[2]. | [IC 50]
12G5 mAb-CXCR4: 0.75 nM (IC50, in SupT1 cells); CXCL12AF647-CXCR4: 18 nM (IC50, in SupT1 cells); X4 HIV-1 (NL4.3): 6.1 nM (IC50, in MT-4 cells); X4 HIV-1 (RF): 7.4 nM (IC50, in MT-4 cells); X4 HIV-1 (HE): 9.8 nM (IC50, in MT-4 cells); X4 HIV-1 (IIIB): 12.3 nM (IC50, in MT-4 cells); X4 HIV-1 (NL4.3AMD3100): 2822 nM (IC50, in MT-4 cells); HIV-2 (ROD): 12.3 nM (IC50, in MT-4 cells); HIV-2 (EHO): 12.3 nM (IC50, in MT-4 cells) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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