| Identification | Back Directory | [Name]
(2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID | [CAS]
186268-78-0 | [Synonyms]
GPI-1485
GPI-1485 L
L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-
(2S)-1-(3,3-Dimethyl-2-oxopentanoyl)-pyrrolidine-2-carboxylic acid
(2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID | [Molecular Formula]
C12H19NO4 | [MDL Number]
MFCD02179274 | [MOL File]
186268-78-0.mol | [Molecular Weight]
241.28 |
| Chemical Properties | Back Directory | [Boiling point ]
386.2±52.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.25±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1]. | [in vivo]
GPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats[1]. | Animal Model: | Adult male Wistar rats, weighing 250-300 g[1] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneal injection; daily; for a total of 42 days | | Result: | Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats. |
| [storage]
Store at -20°C | [References]
[1] Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23. DOI:10.1002/jnr.23033 |
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