| Chemical Properties | Back Directory | [Boiling point ]
650.5±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 25mg/mL, clear | [form ]
powder | [pka]
14.35±0.29(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with
IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. | [Biochem/physiol Actions]
PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor. | [IC 50]
TrkA: 7.7 nM (IC50, in cell-based assays); TrkB: 15 nM (IC50, in cell-based assays); TrkC: 3.9 nM (IC50, in cell-based assays) | [References]
[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633 |
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Sigma-Aldrich
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Energy Chemical
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http://www.energy-chemical.com |
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Merck KGaA
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Biorbyt Ltd.
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MedChemExpress
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