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1863916-87-3

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1863916-87-3 Structure

1863916-87-3 Structure
IdentificationBack Directory
[Name]

Dolutegravir 4-Desfluoro Impurity
[CAS]

1863916-87-3
[Synonyms]

2-Fluoro Dolutegravir
4-Defluoro Dolutegravir
Dolutegravir Impurity 46
Dolutegravir Impurity 49
Doultegravir 2-F Impurity C
Dolutegravir 4-Desfluoro Impurity
Dolutegravir Impurity C (4-Defluoro Dolutegravir)
(4R,12aS)-N-(2-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
Dolutegravir impurity 1/4-Defluoro Dolutegravir/(4R,12aS)-N-(2-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
[Molecular Formula]

C20H20FN3O5
[MOL File]

1863916-87-3.mol
[Molecular Weight]

401.39
Chemical PropertiesBack Directory
[Boiling point ]

671.6±55.0 °C(Predicted)
[density ]

1.49±0.1 g/cm3(Predicted)
[pka]

4.50±1.00(Predicted)
Hazard InformationBack Directory
[Uses]

4-Defluro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
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