| Identification | Back Directory | [Name]
2H-Indol-2-one, 5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro- | [CAS]
186611-56-3 | [Synonyms]
2H-Indol-2-one, 5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro- | [Molecular Formula]
C15H13ClN2O | [MDL Number]
MFCD08443928 | [MOL File]
186611-56-3.mol | [Molecular Weight]
272.73 |
| Chemical Properties | Back Directory | [Boiling point ]
508.6±50.0 °C(Predicted) | [density ]
1.352±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL | [form ]
solid | [pka]
11.52±0.20(Predicted) | [color ]
orange-red | [InChI]
1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19) | [InChIKey]
XLBQNZICMYZIQT-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
A potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells. | [Definition]
ChEBI: SU5614 is a member of the class of oxindoles that is 5-chlorooxindole in which the two hydrogens at position 3 are replaced by a (3,5-dimethylpyrrol-2-yl)methylidene group. It has a role as a vascular endothelial growth factor receptor antagonist. It is a member of pyrroles, a member of oxindoles and an organochlorine compound. | [Biological Activity]
Primary Target
VEGF Flk-1''Target IC50: 1.2 μM2.9 μM against VEGF (Flk-1) and PDGF receptor tyrosine kinasesrespectively; ≤680 nM against the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs) |
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| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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