| Hazard Information | Back Directory | [Uses]
Isotope labelled PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. | [Uses]
It is the isotope labelled analog of Sofosbuvir. Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2?-deoxy-2?-α-fluoro-β-C-methyluridine-5?-monophosphate and is currently being investigated in phase |
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