| Identification | Back Directory | [Name]
MYRISTOYL COENZYME A C14:0 LITHIUM SALT | [CAS]
187100-75-0 | [Synonyms]
Myristoyl CoA lithium salt
MYRISTOYL COENZYME A, LITHIUM
myristoyl coenzyme a lithium salt
N-TETRADECANOYL COENZYME A LITHIUM SALT
MYRISTOYL COENZYME A C14:0 LITHIUM SALT
Coenzyme A S-tetradecanoate lithium salt
Myristoyl coenzyme A lithium salt >=80.0%
coenzyme A myristoyl derivative (C14:0), lithium salt | [Molecular Formula]
C35H63LiN7O17P3S | [MDL Number]
MFCD01310861 | [MOL File]
187100-75-0.mol | [Molecular Weight]
985.84 |
| Hazard Information | Back Directory | [Uses]
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms. | [Biochem/physiol Actions]
Myristoyl coenzyme A is a combination of coenzyme A and myristate. It serves as a substrate in protein myristoylation, catalyzed by the enzyme N-myristoyl transferase. Myristyolation involves the transfer of the myristoyl group to the glycine residue at the amino-terminal of the protein. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158(2):107-13. DOI:10.1007/BF00225835 |
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