| Identification | Back Directory | [Name]
PF-06733804 | [CAS]
1873373-33-1 | [Synonyms]
Trk-IN-3
PF-06733804
PF06733804,PF 06733804
PF-06733804 >=98% (HPLC)
3-Pyridinecarboxamide, 6-amino-5-[[(3S)-4,4-difluoro-1-[2-[4-(trifluoromethoxy)phenyl]acetyl]-3-pyrrolidinyl]oxy]-N-methyl- | [Molecular Formula]
C20H19F5N4O4 | [MDL Number]
MFCD30491880 | [MOL File]
1873373-33-1.mol | [Molecular Weight]
474.38 |
| Chemical Properties | Back Directory | [Boiling point ]
607.6±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [pka]
14.08±0.46(Predicted) | [color ]
white to beige | [InChIKey]
FTAFQADCGCSJAH-HNNXBMFYSA-N | [SMILES]
NC1=C(O[C@H]2CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2(F)F)C=C(C(NC)=O)C=N1 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with
IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. | [Biochem/physiol Actions]
PF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor. | [IC 50]
TrkA: 8.4 nM (IC50, in cell-based assays); TrkB: 6.2 nM (IC50, in cell-based assays); TrkC: 2.2 nM (IC50, in cell-based assays) | [References]
[1] Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. DOI:10.1021/acs.jmedchem.8b00633 |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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