| Identification | Back Directory | [Name]
PNU 109291 | [CAS]
187665-60-7 | [Synonyms]
PNU 109291
(S)-3,4-DIHYDRO-1-[2-[4-(4-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-METHYL-1H-2-BENZOPYRAN-6-CARBOXAMIDE
1H-2-Benzopyran-6-carboxamide, 3,4-dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-, (1S)- | [Molecular Formula]
C24H31N3O3 | [MDL Number]
MFCD10687095 | [MOL File]
187665-60-7.mol | [Molecular Weight]
409.52 |
| Chemical Properties | Back Directory | [Boiling point ]
595.8±50.0 °C(Predicted) | [density ]
1.143±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Powder | [pka]
15.27±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
PNU 109291 is a 5-?HT receptor agonist. | [Biological Activity]
Potent and selective 5-HT 1D receptor agonist that displays > 600-fold selectivity over 5-HT 1A and 5-HT 2A receptors and no activity at 5-HT 1B , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 6 and 5-HT 7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation. | [in vivo]
PNU109291 (0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg; s.c.) reduces dural plasma extravasation evoked by trigeminal ganglion stimulation in pigs[1].
PNU109291 (3 μM) inhibited evoked EPSCs (excitatory postsynaptic currents) in Freund's adjuvant (CFA) but not saline-injected rats[2]. | Animal Model: | 200-500g, male Hartley guinea pigs[1] | | Dosage: | 0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg | | Administration: | S.c.; 60 min before electrical stimulation | | Result: | Dose-dependently decreased plasma protein extravasation with an IC50 value of 4.2 nmol/kg. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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