| Identification | Back Directory | [Name]
2H-Imidazol-2-one, 1-(4-chlorophenyl)-1,5-dihydro-4-(1-piperidinyl)- | [CAS]
188116-08-7 | [Synonyms]
ELB139
ELB-139
ELB 139
1-(4-Chlorophenyl)-1,5-dihydro-4-(1-piperidinyl)-2H-imidazol-2-one
2H-Imidazol-2-one, 1-(4-chlorophenyl)-1,5-dihydro-4-(1-piperidinyl)- | [Molecular Formula]
C14H16ClN3O | [MDL Number]
MFCD09475612 | [MOL File]
188116-08-7.mol | [Molecular Weight]
277.75 |
| Chemical Properties | Back Directory | [Melting point ]
242 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
405.2±47.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [pka]
6.45±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
ELB-139 is a progesterone analogue. ELB-139 is a GABAA receptor partial agonist. ELB-139 has anxiolytic and anticonvulsant activity. ELB-139 induces increase of extracellular 5-HT in the striatum and the medial prefrontal cortex of rats[1][2]. | [References]
[1] Rabe H, et al. The novel anxiolytic ELB139 displays selectivity to recombinant GABA(A) receptors different from diazepam. Neuropharmacology. 2007 Mar;52(3):796-801. DOI:10.1016/j.neuropharm.2006.09.013
[2] Langen B, et al. ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study. Pharmacol Biochem Behav. 2007 Jan;86(1):79-85. DOI:10.1016/j.pbb.2006.12.010 |
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