| Identification | Back Directory | [Name]
PF 06260933 dihydrochloride | [CAS]
1883548-86-4 | [Synonyms]
PF-06260933 HCl
PF-06260933 2HCl
PF 6260933 dihydrochloride
PF 06260933 dihydrochloride | [Molecular Formula]
C16H14Cl2N4 | [MDL Number]
MFCD29049536 | [MOL File]
1883548-86-4.mol | [Molecular Weight]
333.22 |
| Hazard Information | Back Directory | [Description]
PF-06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). It also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). PF-06260933 dihydrochloride has been shown to improves fasting hyperglycemia in mice. ( | [Uses]
PF-06260933 hydrochloride is the hydrochloride form of PF-06260933 (HY-19562). PF-06260933 hydrochloride is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively[1]. | [storage]
Desiccate at RT | [References]
[1] Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. DOI:10.1021/acsmedchemlett.5b00215 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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