| Identification | Back Directory | [Name]
MAFP | [CAS]
188404-10-6 | [Synonyms]
MAFP
MAPF
Phosphonofluoridicacid
METHYL ARACHIDONYL FLUOROPHOSPHONATE
(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester
METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER
5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER
Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester
(5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene
MAPF, Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
(5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENYL-METHYL ESTER PHOSPHONOFLUORIDIC ACID
METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE
Phosphonofluoridic acid, P-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-, methyl ester | [EINECS(EC#)]
201-185-2 | [Molecular Formula]
C21H36FO2P | [MDL Number]
MFCD03095722 | [MOL File]
188404-10-6.mol | [Molecular Weight]
370.48 |
| Chemical Properties | Back Directory | [Boiling point ]
455.3±34.0 °C(Predicted) | [density ]
0.960±0.06 g/cm3(Predicted) | [RTECS ]
TA8108000 | [Fp ]
-16 °C | [storage temp. ]
-70°C | [solubility ]
DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension | [form ]
methyl acetate solution
| [color ]
Light yellow to yellow | [Sensitive ]
Air Sensitive | [InChI]
1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16- | [InChIKey]
KWKZCGMJGHHOKJ-ZKWNWVNESA-N | [SMILES]
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC |
| Hazard Information | Back Directory | [Uses]
(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester, is a cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. | [Definition]
ChEBI: Methyl Arachidonyl Fluorophosphonate is a phosphonic ester. | [Biological Activity]
Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC 50 = 2.5 nM). Also binds irreversibly to CB 1 receptors (IC 50 = 20 nM). | [Biochem/physiol Actions]
MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A2, but not secretory phospholipase A2. MAFP is also a potent acetylcholinesterase inhibitor. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|