Identification | Back Directory | [Name]
Cbz-B3A | [CAS]
1884710-81-9 | [Synonyms]
Cbz-B3A Cbz-B3A >=98% (HPLC) Cbz B3A,Cbz-B-3A,CbzB3A 2,4,10,17-Tetraazaoctadec-3-enedioic acid, 3,8-bis[[(1,1-dimethylethoxy)carbonyl]amino]-9-oxo-, 1-(1,1-dimethylethyl) 18-(phenylmethyl) ester, (8S)- | [Molecular Formula]
C35H58N6O9 | [MDL Number]
MFCD30480922 | [MOL File]
1884710-81-9.mol | [Molecular Weight]
706.87 |
Chemical Properties | Back Directory | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.68±0.46(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1). | [Biological Activity]
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling th at inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation. Cbz-B3A binds to ubiquilins 12and 4which prevents mTORC1 activation. | [storage]
Store at -20°C | [References]
[1] Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291(10):5221-33. DOI:10.1074/jbc.M115.691584 |
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Company Name: |
Energy Chemical
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Tel: |
021-58432009 400-005-6266 |
Website: |
http://www.energy-chemical.com |
Company Name: |
Merck KGaA
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Tel: |
21-20338288 |
Website: |
www.sigmaaldrich.cn |
Company Name: |
MedChemExpress
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Tel: |
021-58955995 |
Website: |
www.medchemexpress.com |
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