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1884710-81-9

1884710-81-9 Structure

1884710-81-9 Structure
IdentificationBack Directory
[Name]

Cbz-B3A
[CAS]

1884710-81-9
[Synonyms]

Cbz-B3A
Cbz-B3A >=98% (HPLC)
Cbz B3A,Cbz-B-3A,CbzB3A
2,4,10,17-Tetraazaoctadec-3-enedioic acid, 3,8-bis[[(1,1-dimethylethoxy)carbonyl]amino]-9-oxo-, 1-(1,1-dimethylethyl) 18-(phenylmethyl) ester, (8S)-
[Molecular Formula]

C35H58N6O9
[MDL Number]

MFCD30480922
[MOL File]

1884710-81-9.mol
[Molecular Weight]

706.87
Chemical PropertiesBack Directory
[density ]

1.14±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

8.68±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
[Biological Activity]

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling th at inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation. Cbz-B3A binds to ubiquilins 12and 4which prevents mTORC1 activation.
[storage]

Store at -20°C
[References]

[1] Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291(10):5221-33. DOI:10.1074/jbc.M115.691584
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