| Chemical Properties | Back Directory | [density ]
1.450±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.895±0.15(predicted) | [color ]
White to off-white | [Sequence]
Cyclo(Ac-Y-{Ala(Me)}-NPHL-{Hyp}-Trp-Ser-{Trp(Me)}-{Nle(Me)}-{Nle(Me)}-{Orn}-Cys)Gly-NH2 (Thioether bridge: Cys14-Ac-Tyr) |
| Hazard Information | Back Directory | [Uses]
WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression[1]. | [IC 50]
RDC Peptide | [References]
[1] Jiang J, et al. Noninvasive evaluation of PD-L1 expression using Copper 64 labeled peptide WL12 by micro-PET imaging in Chinese hamster ovary cell tumor model. Bioorg Med Chem Lett. 2021 May 15;40:127901. DOI:10.1016/j.bmcl.2021.127901 |
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