| Identification | Back Directory | [Name]
ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE | [CAS]
188781-08-0 | [Synonyms]
2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine
ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate ,97%
2-Chloro-4-methyl-5-pyrimidinecarboxylic acid ethyl ester
5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester
2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine, 2-Chloro-5-(ethoxycarbonyl)-4-methyl-1,3-diazine | [Molecular Formula]
C8H9ClN2O2 | [MDL Number]
MFCD03425963 | [MOL File]
188781-08-0.mol | [Molecular Weight]
200.622 |
| Chemical Properties | Back Directory | [Boiling point ]
302.7±22.0 °C(Predicted) | [density ]
1.265 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
solid | [pka]
-2.56±0.29(Predicted) | [color ]
white | [Water Solubility ]
Slightly soluble in water. |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
It is an active pharmaceutical intermediates. | [Synthesis]
The general procedure for the synthesis of ethyl 4-methyl-2-chloropyrimidine-5-carboxylate from ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate was as follows: ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate (10 mmol) was dissolved in phosphorochloride (10 mL), and heated and refluxed for 30 min. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation under reduced pressure. Subsequently, residual phosphorous trichloride was removed by azeotropic distillation with dried benzene. Finally, the crude product was purified by column chromatography to afford pure ethyl 4-methyl-2-chloropyrimidine-5-carboxylate. | [References]
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2290 - 2294
[2] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 70
[3] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 314 - 323 |
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