| Identification | Back Directory | [Name]
H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH | [CAS]
188859-65-6 | [Synonyms]
HSLGKLLGRPDKF
L144, R147-PLP(139-151)
[LEU144, ARG147]-PLP (139-151)
6:PN:WO0053019 SEQID:6 claimed sequence
SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE
HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE
(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151)
H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH
[Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)] | [Molecular Formula]
C67H110N20O17 | [MDL Number]
MFCD00792579 | [MOL File]
188859-65-6.mol | [Molecular Weight]
1467.71 |
| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [pka]
3.49±0.10(Predicted) | [Sequence]
His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe |
| Hazard Information | Back Directory | [Uses]
[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1]. | [References]
[1] Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. DOI:10.1073/pnas.94.17.9279 |
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