| Identification | Back Directory | [Name]
Hydroxytanshinone IIA | [CAS]
18887-18-8 | [Synonyms]
Hydroxytanshinone ⅡA
Hydroxytanshinone IIA
Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-9-hydroxy-1,6,6-trimethyl- | [Molecular Formula]
C19H18O4 | [MOL File]
18887-18-8.mol | [Molecular Weight]
310.34 |
| Chemical Properties | Back Directory | [Boiling point ]
523.6±50.0 °C(Predicted) | [density ]
1.291±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
14.17±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger than the tanshinoneⅡA . | [Uses]
Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2[1]. | [Definition]
ChEBI: Hydroxytanshinone is an abietane diterpenoid. | [References]
[1] Peng Li, et al. Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(5):815-22. DOI:10.1002/rcm.2367 |
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