| Identification | Back Directory | [Name]
danshenol B | [CAS]
189308-09-6 | [Synonyms]
danshenol B
(1R-trans)-1,6,7,8,9,10-Hexahydro-10-hydroxy-1,6,6-trimethyl-10-(2-oxopropyl)-phenanthro[1,2-b]furan-11(2H)-one | [Molecular Formula]
C22H26O4 | [MOL File]
189308-09-6.mol | [Molecular Weight]
354.44 |
| Chemical Properties | Back Directory | [Boiling point ]
501.3±50.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [pka]
11.23±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
Danshenol B has aldose reductase(AR) inhibitory activity. | [Uses]
Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC50 value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy[1]. | [References]
[1] Tezuka Y, et al. Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge. Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11. DOI:10.1248/cpb.45.1306 |
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