| Identification | Back Directory | [Name]
Aminooxy-PEG3-bromide | [CAS]
1895922-73-2 | [Synonyms]
Aminooxy-PEG3-bromide
Aminooxy-PEG3-bromide HCl salt | [Molecular Formula]
C8H18BrNO4 | [MDL Number]
MFCD29764339 | [MOL File]
1895922-73-2.mol | [Molecular Weight]
272.14 |
| Chemical Properties | Back Directory | [Boiling point ]
352.9±32.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [pka]
4.21±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG3-bromide HCl salt is a PEG linker containing an aminooxy group and a bromide group. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|