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189699-82-9

189699-82-9 Structure

189699-82-9 Structure
IdentificationBack Directory
[Name]

FR-188582
[CAS]

189699-82-9
[Synonyms]

FR-188582
1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-
[Molecular Formula]

C16H13ClN2O2S
[MOL File]

189699-82-9.mol
[Molecular Weight]

332.8
Chemical PropertiesBack Directory
[Boiling point ]

539.7±50.0 °C(Predicted)
[density ]

1.33±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

-3.80±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM.
[in vivo]

Oral administration of FR-188582 (0.01-3.2 mg/kg) reverses paw edema in adjuvant arthritic rats and shows a therapeutic effect in a dose-dependent manner with ED50 values (95% C.L.) of 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively. The anti-inflammatory effect of FR-188582 (FR188582) is threefold more potent than that of Indomethacin with ED50 values (95% C.L.) of 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively[1].

[IC 50]

COX-2: 17 nM (IC50)
[storage]

Store at -20°C
[References]

[1] Ochi T, et al. The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats. Jpn J Pharmacol. 2001 Feb;85(2):175-82. DOI:10.1254/jjp.85.175
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