| Identification | Back Directory | [Name]
(2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride | [CAS]
1897379-34-8 | [Synonyms]
SLM6031434 HCl
SLM6031434 (hydrochloride)
SLM-6031434 HCl,SLM6031434 HCl
(S)-2-(3-(4-(Octyloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride
(2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride | [Molecular Formula]
C22H31ClF3N5O2 | [MDL Number]
MFCD31689247 | [MOL File]
1897379-34-8.mol | [Molecular Weight]
489.97 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml | [form ]
A crystalline solid | [color ]
white to beige | [Water Solubility ]
water: ≥2mg/mL |
| Hazard Information | Back Directory | [Uses]
SLM 6031434 Hydrochloride is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibts some selectivity for Sphk2 over Sphk1 (Ki > 20 μM). Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice. | [Biological Activity]
SLM6031434 is a selective sphingosine (Sph) kinase 2 (SK2SphK2SpK2) inhibitor (r/m SphK2 Ki = 400/500 nMr/m SphK1 Ki >20 μM) th at effectively downregulates cellular sphingosine 1-phosphate (S1P) level (47% S1P & 143% Sph of control in U937 post 2h 100 nM SLM6031434 treatment) and selectively reduces plasma S1P in Sphk1-/-but not Sphk2-/- mice in vivo (5 mg/kg i.v.). In contrary to Sphk2-KO miceSLM6031434 treatment enhances plasma S1P in wild-type mice and offers neuroprotective efficacy against ischemic stroke (2 mg/kg i.v. 2h prior to tMCAO). | [storage]
Store at -20°C |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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