| Identification | Back Directory | [Name]
4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 6-bromo-3,7-dihydro-3,7-di-β-D-ribofuranosyl-, cyclic P→5':P'→5''-(dihydrogen diphosphate) | [CAS]
189876-06-0 | [Synonyms]
4H-Pyrrolo[2,3-d]pyrimidin-4-imine, 6-bromo-3,7-dihydro-3,7-di-β-D-ribofuranosyl-, cyclic P→5':P'→5''-(dihydrogen diphosphate) | [Molecular Formula]
C16H21BrN4O13P2 | [MOL File]
189876-06-0.mol | [Molecular Weight]
619.21 |
| Hazard Information | Back Directory | [Uses]
8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) is a potent cADPR antagonist. 8-Br-7-CH-cADPR shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR significantly decreases Paclitaxel (HY-B0015)-induced axon degeneration[1]. | [IC 50]
Calcium Channel | [References]
[1] Yihang Li, et al. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. J Cell Biol. 2022 Feb 7;221(2):e202106080. DOI:10.1083/jcb.202106080 |
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| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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